Amide of Lambertian Acid Suppresses Hyperactivation of Inotropic Glutamate Receptors, but not Synaptic Potentiation in Hippocampal Sections

Amide of Lambertian Acid Suppresses Hyperactivation of Inotropic Glutamate Receptors, but not Synaptic Potentiation in Hippocampal Sections Full article

Journal

Bulletin of Experimental Biology and Medicine
ISSN: 0007-4888

Output data

Year: 2016, Volume: 161, Number: 6, Pages: 782-785 Pages count : 4 DOI: 10.1007/s10517-016-3509-9

Tags

hippocampal sections; hyperactivation of glutamatergic receptors; amide of lambertian acid; post-tetanic synaptic potentiation

Authors

Vechkapova S.O. ¹ , Zapara T.A. ¹ , Morozova E.A. ² , Proskura A.L. ¹ , Schul'ts E.E. ² , Tolstikova T.G. ² , Ratushnyak A.S. ¹

Affiliations

1	Design Technological Institute of Digital Techniques, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia
2	N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia

Amide of lambertian acid suppresses hyperactivation of inotropic glutamate receptors in hippocampal sections induced by a decrease in the level of magnesium ions (a selective blocker of glutamate NMDA receptors). Treatment of the sections with amide of lambertian acid in standard physiological saline does not prevent development of NMDA-dependent synaptic potentiation. Lambertian acid isolated from needles and turpentine of Siberian pine (Pinus sibirica R. Mayr), and its derivatives may become a source of substances with glutamatergic mechanism of action for treatment of cognitive and neurodegenerative disorders.

Vechkapova S.O. , Zapara T.A. , Morozova E.A. , Proskura A.L. , Schul'ts E.E. , Tolstikova T.G. , Ratushnyak A.S.
Amide of Lambertian Acid Suppresses Hyperactivation of Inotropic Glutamate Receptors, but not Synaptic Potentiation in Hippocampal Sections
Bulletin of Experimental Biology and Medicine. 2016. V.161. N6. P.782-785. DOI: 10.1007/s10517-016-3509-9 WOS Scopus РИНЦ

Вечкапова С С.О. , Запара Т.А. , Морозова Е.А. , Проскура А.Л. , Шульц Э.Э. , Толстикова Т.Г. , Ратушняк А.С.
Амид ламбертиановой кислоты подавляет гиперактивацию ионотропных глутаматных рецепторов, но не синаптическую потенциацию в срезах гиппокампа
Бюллетень экспериментальной биологии и медицины (B EXP BIOL MED+). 2016. Т.161. №6. С.736-739. РИНЦ

Published print:	Oct 1, 2016
Published online:	Oct 26, 2016

Web of science	WOS:000387594400011
Scopus	2-s2.0-84992365752
Elibrary	29471944
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