Amide of Lambertian Acid Suppresses Hyperactivation of Inotropic Glutamate Receptors, but not Synaptic Potentiation in Hippocampal Sections

Amide of Lambertian Acid Suppresses Hyperactivation of Inotropic Glutamate Receptors, but not Synaptic Potentiation in Hippocampal Sections Научная публикация

Журнал

Bulletin of Experimental Biology and Medicine
ISSN: 0007-4888

Вых. Данные

Год: 2016, Том: 161, Номер: 6, Страницы: 782-785 Страниц : 4 DOI: 10.1007/s10517-016-3509-9

Ключевые слова

hippocampal sections; hyperactivation of glutamatergic receptors; amide of lambertian acid; post-tetanic synaptic potentiation

Авторы

Vechkapova S.O. ¹ , Zapara T.A. ¹ , Morozova E.A. ² , Proskura A.L. ¹ , Schul'ts E.E. ² , Tolstikova T.G. ² , Ratushnyak A.S. ¹

Организации

1	Design Technological Institute of Digital Techniques, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia
2	N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Division of the Russian Academy of Sciences, Novosibirsk, Russia

Amide of lambertian acid suppresses hyperactivation of inotropic glutamate receptors in hippocampal sections induced by a decrease in the level of magnesium ions (a selective blocker of glutamate NMDA receptors). Treatment of the sections with amide of lambertian acid in standard physiological saline does not prevent development of NMDA-dependent synaptic potentiation. Lambertian acid isolated from needles and turpentine of Siberian pine (Pinus sibirica R. Mayr), and its derivatives may become a source of substances with glutamatergic mechanism of action for treatment of cognitive and neurodegenerative disorders.

Vechkapova S.O. , Zapara T.A. , Morozova E.A. , Proskura A.L. , Schul'ts E.E. , Tolstikova T.G. , Ratushnyak A.S.
Amide of Lambertian Acid Suppresses Hyperactivation of Inotropic Glutamate Receptors, but not Synaptic Potentiation in Hippocampal Sections
Bulletin of Experimental Biology and Medicine. 2016. V.161. N6. P.782-785. DOI: 10.1007/s10517-016-3509-9 WOS Scopus РИНЦ

Вечкапова С С.О. , Запара Т.А. , Морозова Е.А. , Проскура А.Л. , Шульц Э.Э. , Толстикова Т.Г. , Ратушняк А.С.
Амид ламбертиановой кислоты подавляет гиперактивацию ионотропных глутаматных рецепторов, но не синаптическую потенциацию в срезах гиппокампа
Бюллетень экспериментальной биологии и медицины (B EXP BIOL MED+). 2016. Т.161. №6. С.736-739. РИНЦ

Опубликована в печати:	1 окт. 2016 г.
Опубликована online:	26 окт. 2016 г.

Web of science	WOS:000387594400011
Scopus	2-s2.0-84992365752
РИНЦ	29471944
OpenAlex	W2534579283