Abstract: The studies of the condensation of 4-nitrosemicarbazide (4-NSC) with various aldehydes and ketones resulted in the development of an approach to the synthesis of N-nitrosemicarbazones, promising high-energy and biologically active compounds. Subsequent treatment with amines and alkalis led to the synthesis of water-soluble salts of nitrosemicarbazones, as well as the corresponding semicarbazones. The reaction of N,N'-diisopropyl- or N,N'-di-tert-butyl-1,2-ethanediimine with 4-nitrosemicarbazide led to the synthesis of glyoxal bis(nitrosemicarbazone) derivatives. A computer-aided screening using the PASS software showed a probability of high biological activity for the compounds obtained, whereas antiarrhythmic properties of camphor nitrosemicarbazone potassium salt were confirmed in experiments in rats.

Cite: Glukhacheva V.S. , Il'yasov S.G. , Sakovich G.V. , Tolstikova T.G. , Bryzgalov A.O. , Pleshkova N.V.
Synthesis, properties, and application of 4-nitrosemicarbazones
Russian Chemical Bulletin. 2016. V.65. N2. P.550-560. DOI: 10.1007/s11172-016-1336-9 WOS Scopus РИНЦ

ArticleLinkType.TRANSLATED_TO_ORIGINAL: Глухачева В.С. , Ильясов С.Г. , Сакович Г.В. , Толстикова Т.Г. , Брызгалов А.О. , Александрова Н.В.
Синтез, свойства и применение 4-нитросемикарбазонов
Известия Академии наук. Серия химическая.(RUSS CHEM B+). 2016. №2. С.550-560. РИНЦ

Dates:

Published print:	Feb 1, 2016
Published online:	Nov 8, 2016

Identifiers:

Web of science	WOS:000387600700031
Scopus	2-s2.0-85013829723
Elibrary	27275279
OpenAlex	W2554626858

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