Synthesis, properties, and application of 4-nitrosemicarbazones

Synthesis, properties, and application of 4-nitrosemicarbazones Научная публикация

Журнал

Russian Chemical Bulletin
ISSN: 1066-5285 , E-ISSN: 1573-9171

Вых. Данные

Год: 2016, Том: 65, Номер: 2, Страницы: 550-560 Страниц : 11 DOI: 10.1007/s11172-016-1336-9

Ключевые слова

nitrosemicarbazones; nitrosemicarbazide; condensation

Авторы

Glukhacheva V.S. ¹ , Il'yasov S.G. ¹ , Sakovich G.V. ¹ , Tolstikova T.G. ² , Bryzgalov A.O. ² , Pleshkova N.V. ²

Организации

1	(Данные Web of science) Russian Acad Sci, Inst Problems Chem & Energet Technol, Siberian Branch, 1 Ul Sotsialisticheskaya, Biisk Altaiskogo Kraya 659322, Russia
2	(Данные Web of science) Russian Acad Sci, Siberian Branch, NN Vorozhtsov Novosibirsk Inst Organ Chem, 9 Prosp Akad Lavrenteva, Novosibirsk 630090, Russia

The studies of the condensation of 4-nitrosemicarbazide (4-NSC) with various aldehydes and ketones resulted in the development of an approach to the synthesis of N-nitrosemicarbazones, promising high-energy and biologically active compounds. Subsequent treatment with amines and alkalis led to the synthesis of water-soluble salts of nitrosemicarbazones, as well as the corresponding semicarbazones. The reaction of N,N'-diisopropyl- or N,N'-di-tert-butyl-1,2-ethanediimine with 4-nitrosemicarbazide led to the synthesis of glyoxal bis(nitrosemicarbazone) derivatives. A computer-aided screening using the PASS software showed a probability of high biological activity for the compounds obtained, whereas antiarrhythmic properties of camphor nitrosemicarbazone potassium salt were confirmed in experiments in rats.

Glukhacheva V.S. , Il'yasov S.G. , Sakovich G.V. , Tolstikova T.G. , Bryzgalov A.O. , Pleshkova N.V.
Synthesis, properties, and application of 4-nitrosemicarbazones
Russian Chemical Bulletin. 2016. V.65. N2. P.550-560. DOI: 10.1007/s11172-016-1336-9 WOS Scopus РИНЦ

Глухачева В.С. , Ильясов С.Г. , Сакович Г.В. , Толстикова Т.Г. , Брызгалов А.О. , Александрова Н.В.
Синтез, свойства и применение 4-нитросемикарбазонов
Известия Академии наук. Серия химическая.(RUSS CHEM B+). 2016. №2. С.550-560. РИНЦ

Опубликована в печати:	1 февр. 2016 г.
Опубликована online:	8 нояб. 2016 г.

Web of science	WOS:000387600700031
Scopus	2-s2.0-85013829723
РИНЦ	27275279
OpenAlex	W2554626858