Use of the Mannich Reaction to Synthesize Spin-Labeled Derivatives of the Natural Flavonoid Dihydroquercetin Full article
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Chemistry of Natural Compounds
ISSN: 0009-3130 , E-ISSN: 1573-8388 |
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| Output data | Year: 2014, Volume: 50, Number: 2, Pages: 261-265 Pages count : DOI: 10.1007/s10600-014-0927-7 | ||
| Tags | dihydroquercetin; nitroxyl radicals; spin-labeled compounds; Mannich reaction | ||
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Abstract:
Mono-substituted spin-labeled compounds were synthesized from Mannich reactions of dihydroquercetin with 4-amino-2,2,6,6-tetramethylpiperidine-1-oxyl, 3-amino-2,2,5,5-tetramethylpyrrolidine-1-oxyl, and 3-aminomethyl-2,2,5,5-tetramethylpyrrolidine-1-oxyl. According to preliminary data, the compounds possessed antioxidant activity and selective cytotoxicity against various tumor cells and were promising for biomedical tests including magnetic resonance tomography.
Cite:
Kosheleva N.V.
, Chernyak E.I.
, Polienko Y.F.
, Morozov S.V.
, Grigor'ev I.A.
Use of the Mannich Reaction to Synthesize Spin-Labeled Derivatives of the Natural Flavonoid Dihydroquercetin
Chemistry of Natural Compounds. 2014. V.50. N2. P.261-265. DOI: 10.1007/s10600-014-0927-7 WOS Scopus РИНЦ OpenAlex
Use of the Mannich Reaction to Synthesize Spin-Labeled Derivatives of the Natural Flavonoid Dihydroquercetin
Chemistry of Natural Compounds. 2014. V.50. N2. P.261-265. DOI: 10.1007/s10600-014-0927-7 WOS Scopus РИНЦ OpenAlex
Dates:
| Published print: | May 1, 2014 |
| Published online: | May 13, 2014 |
Identifiers:
| Web of science: | WOS:000336800200014 |
| Scopus: | 2-s2.0-84903160656 |
| Elibrary: | 24061513 |
| OpenAlex: | W1993935343 |