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Chelidonic Acid and Its Derivatives from Saussurea Controversa: Isolation, Structural Elucidation and Influence on the Osteogenic Differentiation of Multipotent Mesenchymal Stromal Cells In Vitro Научная публикация

Журнал Biomolecules
ISSN: 2218-273X
Вых. Данные Год: 2019, Том: 9, Номер: 5, Номер статьи : 189, Страниц : DOI: 10.3390/biom9050189
Ключевые слова Saussurea controversa DC (Asteraceae); chelidonic acid; 4-oxo-4H-pyran-2; 6-dicarboxylic acid esters; X-ray diffraction analysis; human multipotent mesenchymal stromal cells
Авторы Avdeeva Elena 1 , Shults Elvira 2,3 , Rybalova Tatyana 3,4 , Reshetov Yaroslav 1 , Porokhova Ekaterina 5 , Sukhodolo Irina 5 , Litvinova Larisa 6 , Shupletsova Valeria 6 , Khaziakhmatova Olga 6 , Khlusov Igor 5,7 , Guryev Artem 1 , Belousov Mikhail 1,7
Организации
1 (Данные Web of science) Siberian State Med Univ, Dept Pharmaceut Anal, Tomsk 634050, Russia
2 (Данные Web of science) Novosibirsk Inst Organ Chem, Lab Med Chem, Siberian Branch, Novosibirsk 630090, Russia
3 (Данные Web of science) Novosibirsk State Univ, 2 Pirogova St, Novosibirsk 630090, Russia
4 (Данные Web of science) Novosibirsk Inst Organ Chem, Siberian Branch, Ctr Spectral Invest, Novosibirsk 630090, Russia
5 (Данные Web of science) Siberian State Med Univ, Dept Morphol & Gen Pathol, Tomsk 634050, Russia
6 (Данные Web of science) Immanuel Kant Baltic Fed Univ, Basic Lab Immunol & Cell Biotechnol, Kaliningrad 236041, Russia
7 (Данные Web of science) Tomsk Polytech Univ, Res Sch Chem & Appl Biomed Sci, Tomsk 634050, Russia

Реферат: 4-oxo-4H-pyran-2.6-dicarboxylic acid (chelidonic acid, ChA) in the native state and in the complex with calcium [Ca(ChA)(H2O)(3)], named saucalchelin (CaChA), was isolated from the extract of Saussurea controversa leaves for the first time for the Asteraceae family. The structure of ChA was determined by NMR, MS and confirmed by X-ray analysis of its monomethyl ester, and CaChA was described by IR, ICP-MS, CHN analysis. The yield of ChA and CaChA was 45 mg/g and 70 mg/g of extract, respectively. The osteogenic activity of ChA, n-monobutyl ester of chelidonic acid, and CaChA has been studied in vitro in a 21-day culture of human adipose-derived multipotent mesenchymal stromal cells (hAMMSCs) in a standard nutrient medium without osteogenic supplements. CaChA significantly stimulated the growth of cell mass and differentiation of hAMMSCs into osteoblasts with subsequent mineralization of the culture and it may be a promising substance for accelerating bone tissue regeneration and engineering.
Библиографическая ссылка: Avdeeva E. , Shults E. , Rybalova T. , Reshetov Y. , Porokhova E. , Sukhodolo I. , Litvinova L. , Shupletsova V. , Khaziakhmatova O. , Khlusov I. , Guryev A. , Belousov M.
Chelidonic Acid and Its Derivatives from Saussurea Controversa: Isolation, Structural Elucidation and Influence on the Osteogenic Differentiation of Multipotent Mesenchymal Stromal Cells In Vitro
Biomolecules. 2019. V.9. N5. 189 . DOI: 10.3390/biom9050189 WOS Scopus РИНЦ OpenAlex
Файлы: Полный текст от издателя
Даты:
Опубликована online: 16 мая 2019 г.
Идентификаторы БД:
Web of science: WOS:000472671400029
Scopus: 2-s2.0-85066234373
РИНЦ: 41629254
OpenAlex: W2945610555
Цитирование в БД:
БД Цитирований
Web of science 15
Scopus 17
РИНЦ 21
OpenAlex 19
Альметрики: