Synthesis of fully functionalized spirostanic 1,2,3-triazoles by the three component reaction of diosgenin azides with acetophenones and aryl aldehydes and their biological evaluation as antiproliferative agents Научная публикация
| Журнал |
Steroids
ISSN: 0039-128X , E-ISSN: 1878-5867 |
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| Вых. Данные | Год: 2023, Том: 190, Страницы: 109133 Страниц : 1 DOI: 10.1016/j.steroids.2022.109133 | ||||||
| Ключевые слова | Spirostanes, Steroids, Diosgenin, Click chemistry, Cytotoxicity | ||||||
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Реферат:
Diosgenin is of significant interest due to its biological activity and synthetic application. In this study, we report
the synthesis of a series of spirostanic 1,4,5-trisubstituted 1,2,3-triazoles by the three component reaction of
(25R)-6-azidospirostan-3,5-diols with acetophenones and aryl aldehydes. The one-pot two step synthesis proceeds through the in situ formation of (E)-chalcones and copper catalyzed reaction with organic azides in DMF
medium. Structural diversity was achieved by varying the aldehyde and acetophenone nature as well as the
spirostanic azide stereochemistry. The results of in vitro biological assays showed that fully decorated spirostanic
1,2,3-triazoles exerted significant and selective antiproliferative activity against MCF-7, glioblastoma (SNB-19,
T98G, A-172) and neuroblastoma (IMR-32, SH-SYSY) (HCT116) cell lines (GI50 in the single-digit micromolar
range). The data revealed that benzoyl and aryl substitutions in the triazole ring introduced at the 6β-position
significantly improved the anti-tumor activity of (25R)-6-azidospirostan-3β,5α-diols. This position on the spirostan core may be the favourable to synthesize of potent anticancer leads from diosgenin.
Библиографическая ссылка:
Mironov M.E.
, Rybalova T.V.
, Pokrovskii M.A.
, Emaminia F.
, Gandalipov E.R.
, Pokrovskii A.G.
, Shults E.E.
Synthesis of fully functionalized spirostanic 1,2,3-triazoles by the three component reaction of diosgenin azides with acetophenones and aryl aldehydes and their biological evaluation as antiproliferative agents
Steroids. 2023. V.190. P.109133. DOI: 10.1016/j.steroids.2022.109133 WOS РИНЦ OpenAlex
Synthesis of fully functionalized spirostanic 1,2,3-triazoles by the three component reaction of diosgenin azides with acetophenones and aryl aldehydes and their biological evaluation as antiproliferative agents
Steroids. 2023. V.190. P.109133. DOI: 10.1016/j.steroids.2022.109133 WOS РИНЦ OpenAlex
Даты:
| Поступила в редакцию: | 1 сент. 2022 г. |
| Принята к публикации: | 23 окт. 2022 г. |
| Опубликована online: | 31 окт. 2022 г. |
Идентификаторы БД:
| Web of science: | WOS:000910436600001 |
| РИНЦ: | 54068089 |
| OpenAlex: | W4307896430 |