Synthesis and Antibacterial Activity of Caffeine Derivatives Containing Amino-Acid Fragments

Synthesis and Antibacterial Activity of Caffeine Derivatives Containing Amino-Acid Fragments Научная публикация

Журнал

Chemistry of Natural Compounds
ISSN: 0009-3130 , E-ISSN: 1573-8388

Вых. Данные

Год: 2022, Том: 58, Номер: 5, Страницы: 908-915 Страниц : 8 DOI: 10.1007/s10600-022-03826-3

Ключевые слова

caffeine xanthines amino acids catalytic amination antibacterial activity

Авторы

Reshetnikov D.V. ¹ , Burova L.G. ² , Rybalova T.V. ¹ , Bondareva E.A. ² , Patrushev S.S. ^1,3 , Evstropov A.N. ² , Shults E.E. ¹

Организации

1	N.N. Vorozhtsov Novosibirsk Institute of Organic Chemistry of Siberian Branch of Russian Academy of Sciences
2	Новосибирский государственный медицинский университет
3	Novosibirsk State University

Cross-coupling of 8-bromocaffeine, 8-bromo-1-butyltheobromine, or 8-bromo-7-butyltheophylline with α-, β-, or ω-amino-acid methyl or t-butyl ester hydrochlorides in toluene in the presence of the catalytic system Pd(OAc)2·XantPhos and Cs2CO3 with microwave activation led to the formation of xanthine derivatives containing amino-acid fragments in the C-8 position. The antibacterial activity against Staphylococcus aureus and Bacillus cereus was studied.

Reshetnikov D.V. , Burova L.G. , Rybalova T.V. , Bondareva E.A. , Patrushev S.S. , Evstropov A.N. , Shults E.E.
Synthesis and Antibacterial Activity of Caffeine Derivatives Containing Amino-Acid Fragments
Chemistry of Natural Compounds. 2022. V.58. N5. P.908-915. DOI: 10.1007/s10600-022-03826-3 WOS РИНЦ OpenAlex

Поступила в редакцию:	11 апр. 2022 г.
Опубликована online:	24 сент. 2022 г.

Web of science:	WOS:000857801500007
РИНЦ:	51541768
OpenAlex:	W4297175547

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