Synthesis of 5-methyl-4-polyfluoroaryl-1,3-thiazol-2-amines

Synthesis of 5-methyl-4-polyfluoroaryl-1,3-thiazol-2-amines Full article

Journal

Mendeleev Communications
ISSN: 0959-9436

Output data

Year: 2024, Volume: 34, Number: 2, Pages: 277-278 Pages count : 2 DOI: 10.1016/j.mencom.2024.02.038

Tags

thiazoles; α-bromo ketones; organofluorine compounds; bromination; thiourea; X-ray diffraction analysis

Authors

Kalashnikov Stepan B. ^1,2 , Vinogradov Andrey S. ¹ , Bagryanskaya Irina Yu. ¹ , Mezhenkova Tatyana V. ¹

Affiliations

1	N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch of the Russian Academy of Sciences
2	Department of Natural Sciences, Novosibirsk State University

Funding (1)

Российский Научный Фонд

23-23-00547

1-(Polyfluoroaryl)propan-1-ones were transformed into 5-methyl-4-polyfluoroaryl-1,3-thiazol-2-amines by a twostep reaction sequence involving formation of 2-bromo-1- (polyfluoroaryl)propan-1-ones under the acidic bromination conditions followed by heterocyclization with thiourea to finally afford new 5-methyl-4-polyfluoroaryl-1,3-thiazol-2- amines in high yields. 1,1'-(2,3,5,6-Tetrafluoro-1,4-phenylene)- dipropan-1-one was involved in the similar reaction to give a derivative containing two thiazole moieties.

Kalashnikov S.B. , Vinogradov A.S. , Bagryanskaya I.Y. , Mezhenkova T.V.
Synthesis of 5-methyl-4-polyfluoroaryl-1,3-thiazol-2-amines
Mendeleev Communications. 2024. V.34. N2. P.277-278. DOI: 10.1016/j.mencom.2024.02.038 WOS OpenAlex

Submitted:	Nov 29, 2023
Published print:	Apr 3, 2024

Web of science:	WOS:001225073000001
OpenAlex:	W4393856652

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