Synthesis of New Compounds Combining Adamantanamine and Monoterpene Fragments and their Antiviral Activity Against Influenza Virus A(H1N1)pdm09 Full article
| Journal |
Letters in Drug Design and Discovery
ISSN: 1570-1808 , E-ISSN: 1875-628X |
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| Output data | Year: 2013, Volume: 10, Number: 6, Pages: 477-485 Pages count : DOI: 10.2174/1570180811310060002 | ||||
| Tags | Adamantyamine; Antiviral; (H1N1)pdm09; Influenza; Monoterpenoid; Resistance | ||||
| Authors |
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Abstract:
A set of new nitrogen-containing compounds with adamantane and monoterpene frameworks was synthesized. The antiviral activity of the amine products against the influenza virus A/California/07/09 (H1N1)pdm09 was studied. The introduction of a monoterpenoid fragment led to increase of the antiviral activity of adamantylamine derivatives against adamantylamine resistant virus: the selectivity index of the majority of the synthesized amines was higher than that of rimantadine and amantadine.
Cite:
Teplov G.V.
, Suslov E.V.
, Zarubaev V.V.
, Shtro A.A.
, Karpinskaya L.A.
, Rogachev A.D.
, Korchagina D.V.
, Volcho K.P.
, Salakhutdinov N.F.
, Kiselev O.I.
Synthesis of New Compounds Combining Adamantanamine and Monoterpene Fragments and their Antiviral Activity Against Influenza Virus A(H1N1)pdm09
Letters in Drug Design and Discovery. 2013. V.10. N6. P.477-485. DOI: 10.2174/1570180811310060002 WOS Scopus РИНЦ OpenAlex
Synthesis of New Compounds Combining Adamantanamine and Monoterpene Fragments and their Antiviral Activity Against Influenza Virus A(H1N1)pdm09
Letters in Drug Design and Discovery. 2013. V.10. N6. P.477-485. DOI: 10.2174/1570180811310060002 WOS Scopus РИНЦ OpenAlex
Dates:
| Published print: | May 1, 2013 |
Identifiers:
| Web of science: | WOS:000318995000001 |
| Scopus: | 2-s2.0-84879756004 |
| Elibrary: | 20438885 |
| OpenAlex: | W2321237620 |