Acylation of Azepanoglycyrrhetol | Sciact

Acylation of Azepanoglycyrrhetol Full article

Journal

Chemistry of Natural Compounds
ISSN: 0009-3130 , E-ISSN: 1573-8388

Output data

Year: 2024, Volume: 60, Number: 6, Pages: 1066-1071 Pages count : 6 DOI: 10.1007/s10600-024-04521-1

Tags

glycyrrhetinic acid synthesis azepanotriterpenoids cytotoxicity

Authors

Terekhova A.V. ¹ , Petrova A.V. ¹ , Kazakova O.B. ¹ , Vakhitova Yu.V. ² , Polovyanenko D.N. ³ , Bagryanskaya I.Yu. ³

Affiliations

1	Ufa Institute of Chemistry, Ufa Federal Research Center, Russian Academy of Sciences
2	Institute of Biochemistry and Genetics, Ufa Federal Research Center, Russian Academy of Sciences
3	N. N. Vorozhtsov Novosibirsk Institute of Organic Chemistry, Siberian Branch, Russian Academy of Sciences

Acylation of azepano-11-deoxoglycyrrhetol synthesized N-acetyl- and N,O-bis-acetyl derivatives. The structure of azepano-11-deoxoglycyrrhetol was confirmed by an XSA. Data for its influence on cell cycle progression suggested that suppression of cell survival was due primarily to a cytostatic effect that was related to arrest of the S or G1 phase, depending on the cell line.

Terekhova A.V. , Petrova A.V. , Kazakova O.B. , Vakhitova Y.V. , Polovyanenko D.N. , Bagryanskaya I.Y.
Acylation of Azepanoglycyrrhetol
Chemistry of Natural Compounds. 2024. V.60. N6. P.1066-1071. DOI: 10.1007/s10600-024-04521-1 WOS Scopus OpenAlex

Submitted:	Mar 10, 2024
Published online:	Nov 8, 2024

Web of science:	WOS:001351186100009
Scopus:	2-s2.0-85208783404
OpenAlex:	W4404196893

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