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Study of skin anti-ageing and anti-inflammatory effects of dihydroquercetin, natural triterpenoinds, and their synthetic derivatives Full article

Journal Russian Journal of Bioorganic Chemistry
ISSN: 1068-1620
Output data Year: 2012, Volume: 38, Number: 3, Pages: 328-334 Pages count : DOI: 10.1134/S1068162012030028
Tags collagenase-1; triterpenoids; dihydroquercetin; photoageing; interleukin-8
Authors Lee Chan Woo 2 , Park Nok Hyun 2 , Kim Jin Woong 3 , Um Byung Hun 4 , Shpatov A. V. 1 , Shults E. E. 1 , Sorokina I. V. 1 , Popov S. A. 1
Affiliations
1 (Данные Web of science) Novosibirsk Organ Chem Inst, Novosibirsk 630090, Russia
2 (Данные Web of science) Amore Pacific Co, R&D Ctr, Yongin 446729, Gyeonggi Do, South Korea
3 (Данные Web of science) Hanyang Univ, Dept Appl Chem, Ansan 426791, Kyeonggi Do, South Korea
4 (Данные Web of science) Korea Inst Sci & Technol KIST, Gangneung Inst, Nat Prod Res Ctr, Kangnung 210340, Gangwon Do, South Korea

Abstract: Accessible triterpenoids of ursane and lupane series, the flavonoid dihydroquercetin and their synthetic derivatives with polar substituents were tested in vitro for inhibition of collagenase 1 (MMP-1) in UVB irradiation assay. Ursolic acid and uvaol disuccinate were the most active inhibitors in the ursane series. In the lupane series, the best inhibition was manifested by carboxymethyl ester of betulonic acid and betulin succinates. Down- regulation of MMP-1 by dihydroquercetin and its synthetic derivatives surpassed the activity of a standard (retinoic acid).
Cite: Lee C.W. , Park N.H. , Kim J.W. , Um B.H. , Shpatov A.V. , Shults E.E. , Sorokina I.V. , Popov S.A.
Study of skin anti-ageing and anti-inflammatory effects of dihydroquercetin, natural triterpenoinds, and their synthetic derivatives
Russian Journal of Bioorganic Chemistry. 2012. V.38. N3. P.328-334. DOI: 10.1134/S1068162012030028 WOS Scopus РИНЦ OpenAlex
Dates:
Published print: May 1, 2012
Published online: May 23, 2012
Identifiers:
Web of science: WOS:000304408900013
Scopus: 2-s2.0-84865457787
Elibrary: 20471406
OpenAlex: W2028426733
Citing:
DB Citing
Web of science 14
Scopus 12
Elibrary 14
OpenAlex 21
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