Synthesis and Pro-Apoptotic Activity of Novel Glycyrrhetinic Acid Derivatives Full article
| Journal |
ChemBioChem
ISSN: 1439-4227 , E-ISSN: 1439-7633 |
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| Output data | Year: 2011, Volume: 12, Number: 5, Pages: 784-794 Pages count : 11 DOI: 10.1002/cbic.201000618 | ||||
| Tags | antitumor agents; apoptosis; biological activity; glycyrrhetinic acid derivatives; medicinal chemistry | ||||
| Authors |
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Abstract:
Triterpenoids are used for medicinal purposes in many countries. Some, such as oleanolic and glycyrrhetinic acids, are known to be anti-inflammatory and anticarcinogenic. However, the biological activities of these naturally occurring molecules against their particular targets are weak, so the synthesis of new synthetic analogues with enhanced potency is needed. By combining modifications to both the A and C rings of 18 beta H-glycyrrhetinic acid, the novel synthetic derivative methyl 2-cyano-3,12-dioxo-18bH-olean-9(11), 1(2)-dien-30-oate was obtained. This derivative displays high antiproliferative activity in cancer cells, including a cell line with a multidrug-resistance phenotype. It causes cell death by inducing the intrinsic caspase-dependent apoptotic pathway.
Cite:
Logashenko E.B.
, Salomatina O.V.
, Markov A.V.
, Korchagina D.V.
, Salakhutdinov N.F.
, Tolstikov G.A.
, Vlassov V.V.
, Zenkova M.A.
Synthesis and Pro-Apoptotic Activity of Novel Glycyrrhetinic Acid Derivatives
ChemBioChem. 2011.
V.12. N5. P.784-794. DOI: 10.1002/cbic.201000618
WOS
Scopus
РИНЦ
OpenAlex
Synthesis and Pro-Apoptotic Activity of Novel Glycyrrhetinic Acid Derivatives
ChemBioChem. 2011.
V.12. N5. P.784-794. DOI: 10.1002/cbic.201000618
WOS
Scopus
РИНЦ
OpenAlex
Files:
Full text from publisher
Dates:
| Published online: | Feb 15, 2011 |
| Published print: | Mar 21, 2011 |
Identifiers:
| Web of science: | WOS:000288563000019 |
| Scopus: | 2-s2.0-79952638583 |
| Elibrary: | 16663570 |
| OpenAlex: | W2053131185 |