Synthesis and Pro-Apoptotic Activity of Novel Glycyrrhetinic Acid Derivatives Научная публикация
| Журнал |
ChemBioChem
ISSN: 1439-4227 , E-ISSN: 1439-7633 |
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| Вых. Данные | Год: 2011, Том: 12, Номер: 5, Страницы: 784-794 Страниц : 11 DOI: 10.1002/cbic.201000618 | ||||
| Ключевые слова | antitumor agents; apoptosis; biological activity; glycyrrhetinic acid derivatives; medicinal chemistry | ||||
| Авторы |
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| Организации |
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Реферат:
Triterpenoids are used for medicinal purposes in many countries. Some, such as oleanolic and glycyrrhetinic acids, are known to be anti-inflammatory and anticarcinogenic. However, the biological activities of these naturally occurring molecules against their particular targets are weak, so the synthesis of new synthetic analogues with enhanced potency is needed. By combining modifications to both the A and C rings of 18 beta H-glycyrrhetinic acid, the novel synthetic derivative methyl 2-cyano-3,12-dioxo-18bH-olean-9(11), 1(2)-dien-30-oate was obtained. This derivative displays high antiproliferative activity in cancer cells, including a cell line with a multidrug-resistance phenotype. It causes cell death by inducing the intrinsic caspase-dependent apoptotic pathway.
Библиографическая ссылка:
Logashenko E.B.
, Salomatina O.V.
, Markov A.V.
, Korchagina D.V.
, Salakhutdinov N.F.
, Tolstikov G.A.
, Vlassov V.V.
, Zenkova M.A.
Synthesis and Pro-Apoptotic Activity of Novel Glycyrrhetinic Acid Derivatives
ChemBioChem. 2011.
V.12. N5. P.784-794. DOI: 10.1002/cbic.201000618
WOS
Scopus
РИНЦ
OpenAlex
Synthesis and Pro-Apoptotic Activity of Novel Glycyrrhetinic Acid Derivatives
ChemBioChem. 2011.
V.12. N5. P.784-794. DOI: 10.1002/cbic.201000618
WOS
Scopus
РИНЦ
OpenAlex
Файлы:
Полный текст от издателя
Даты:
| Опубликована online: | 15 февр. 2011 г. |
| Опубликована в печати: | 21 мар. 2011 г. |
Идентификаторы БД:
| Web of science: | WOS:000288563000019 |
| Scopus: | 2-s2.0-79952638583 |
| РИНЦ: | 16663570 |
| OpenAlex: | W2053131185 |