A combinatorially convenient version of synthesis of 5-substituted oxazole-4-carboxylic acid ethyl esters Full article
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Russian Journal of Organic Chemistry
ISSN: 1070-4280 , E-ISSN: 1608-3393 |
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| Output data | Year: 2006, Volume: 42, Number: 7, Pages: 1031-1035 Pages count : 5 DOI: 10.1134/S1070428006070177 | ||
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Abstract:
Reaction of ethyl isocyanoacetic acid with sodium hydride in anhydrous benzene, followed by treatment with carboxylic acid chlorides or N-(acyloxy)pyrrolidine-2,5-diones, gives 5-substituted oxazole-4-carboxylic acid esters. The procedure is applicable to derivatives of various carboxylic acids, including saturated aliphatic, alpha,beta-unsaturated, alicyclic, aromatic, heterocyclic, and N-Boc-protected amino acids.
Cite:
Tormyshev V.M.
, Mikhalina T.V.
, Rogozhnikova O.Y.
, Troitskaya T.I.
, Trukhin D.V.
A combinatorially convenient version of synthesis of 5-substituted oxazole-4-carboxylic acid ethyl esters
Russian Journal of Organic Chemistry. 2006. V.42. N7. P.1031-1035. DOI: 10.1134/S1070428006070177 WOS Scopus РИНЦ OpenAlex
A combinatorially convenient version of synthesis of 5-substituted oxazole-4-carboxylic acid ethyl esters
Russian Journal of Organic Chemistry. 2006. V.42. N7. P.1031-1035. DOI: 10.1134/S1070428006070177 WOS Scopus РИНЦ OpenAlex
Original:
Тормышев В.М.
, Михалина Т.В.
, Рогожникова О.Ю.
, Троицкая Т.И.
, Трухин Д.В.
Удобный для применения в комбинаторной химии вариант синтеза этиловых эфиров 5-замещенных оксазол-4-карбоновых кислот
Журнал органической химии (RUSS J ORG CHEM+). 2006. Т.42. №7. С.1049-1053. РИНЦ
Удобный для применения в комбинаторной химии вариант синтеза этиловых эфиров 5-замещенных оксазол-4-карбоновых кислот
Журнал органической химии (RUSS J ORG CHEM+). 2006. Т.42. №7. С.1049-1053. РИНЦ
Dates:
| Published print: | Jul 1, 2006 |
Identifiers:
| Web of science: | WOS:000240078600017 |
| Scopus: | 2-s2.0-33747179597 |
| Elibrary: | 13508389 |
| OpenAlex: | W2953280084 |