Synthesis and analgesic activity of 1,3,5-trisubstituted pyrazoles containing a diterpenoid moiety Full article
| Journal |
Russian Chemical Bulletin
ISSN: 1066-5285 , E-ISSN: 1573-9171 |
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| Output data | Year: 2020, Volume: 69, Number: 3, Pages: 537-546 Pages count : 10 DOI: 10.1007/s11172-020-2795-6 | ||||
| Tags | diterpenoids; furanolabdanoids; phlomisoic acid; alkyne-1; 2-diones; phenyl-hydrazines; pyrazoles; Castro-Stephens cross-coupling; heterocyclization; X-ray diffraction | ||||
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Abstract:
Conjugates of terpenoids with 1,3,5-trisubstituted pyrazoles were synthesized by the cross-coupling of methyl 16-(2-chloro-2-oxoacetyl)labdatrienoate with terminal arylacetylenes via the Castro-Stephens reaction and heterocyclization of arylalkyne-1,2-diones with arylhydr-azines. The structure of one reaction product was established by X-ray diffraction. The conditions for the formation of furanolabdanoid arylalkyne-1,2-diones were found. The newly synthesized pyrazoles exhibit analgesic activity in a model of chemical irritation.
Cite:
Mironov M.E.
, Poltanovich A.I.
, Rybalova T.V.
, Dolgikh M.P.
, Tolstikova T.G.
, Shults E.E.
Synthesis and analgesic activity of 1,3,5-trisubstituted pyrazoles containing a diterpenoid moiety
Russian Chemical Bulletin. 2020. V.69. N3. P.537-546. DOI: 10.1007/s11172-020-2795-6 WOS Scopus РИНЦ OpenAlex
Synthesis and analgesic activity of 1,3,5-trisubstituted pyrazoles containing a diterpenoid moiety
Russian Chemical Bulletin. 2020. V.69. N3. P.537-546. DOI: 10.1007/s11172-020-2795-6 WOS Scopus РИНЦ OpenAlex
Original:
Миронов М.Е.
, Полтанович А.И.
, Рыбалова Т.В.
, Долгих М.П.
, Толстикова Т.Г.
, Шульц Э.Э.
СИНТЕЗ И АНАЛЬГЕТИЧЕСКАЯ АКТИВНОСТЬ 1,3,5-ТРИЗАМЕЩЕННЫХ ПИРАЗОЛОВ, СОДЕРЖАЩИХ ДИТЕРПЕНОИДНЫЙ ФРАГМЕНТ
Известия Академии наук. Серия химическая.(RUSS CHEM B+). 2020. №3. С.537-546. РИНЦ
СИНТЕЗ И АНАЛЬГЕТИЧЕСКАЯ АКТИВНОСТЬ 1,3,5-ТРИЗАМЕЩЕННЫХ ПИРАЗОЛОВ, СОДЕРЖАЩИХ ДИТЕРПЕНОИДНЫЙ ФРАГМЕНТ
Известия Академии наук. Серия химическая.(RUSS CHEM B+). 2020. №3. С.537-546. РИНЦ
Dates:
| Published print: | Mar 1, 2020 |
| Published online: | Apr 8, 2020 |
Identifiers:
| Web of science: | WOS:000524864600015 |
| Scopus: | 2-s2.0-85083298965 |
| Elibrary: | 43265168 |
| OpenAlex: | W3015810743 |