Usnic Acid Derivatives Are Effective Inhibitors of Tyrosyl-DNA Phosphodiesterase 1 Научная публикация
| Журнал |
Russian Journal of Bioorganic Chemistry
ISSN: 1068-1620 |
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| Вых. Данные | Год: 2017, Том: 43, Номер: 1, Страницы: 84-90 Страниц : 7 DOI: 10.1134/S1068162017010125 | ||||||||
| Ключевые слова | tyrosyl-DNA phosphodiesterase 1; tyrosyl-DNA phosphodiesterase 1 inhibitors; usnic acid | ||||||||
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Реферат:
The synthesis of (+)-usnic acid derivatives is described. The derivatives contain one or two cyano groups, connected to the acetophenone fragment of dibenzofuran core by linkers of different length and character, or some other modifications. The influence of these compounds on the activity of recombinant human tyrosyl-DNA phosphodiesterase 1 and MCF-7 tumor cells' viability has been estimated. The data indicate a distinct dependence of functional characteristics of the compounds on their structure.
Библиографическая ссылка:
Zakharenko A.L.
, Luzina O.A.
, Sokolov D.N.
, Zakharova O.D.
, Rakhmanova M.E.
, Chepanova A.A.
, Dyrkheeva N.S.
, Lavrik O.I.
, Salakhutdinov N.F.
Usnic Acid Derivatives Are Effective Inhibitors of Tyrosyl-DNA Phosphodiesterase 1
Russian Journal of Bioorganic Chemistry. 2017. V.43. N1. P.84-90. DOI: 10.1134/S1068162017010125 WOS Scopus РИНЦ OpenAlex
Usnic Acid Derivatives Are Effective Inhibitors of Tyrosyl-DNA Phosphodiesterase 1
Russian Journal of Bioorganic Chemistry. 2017. V.43. N1. P.84-90. DOI: 10.1134/S1068162017010125 WOS Scopus РИНЦ OpenAlex
Даты:
| Опубликована в печати: | 1 янв. 2017 г. |
| Опубликована online: | 14 февр. 2017 г. |
Идентификаторы БД:
| Web of science: | WOS:000396423800012 |
| Scopus: | 2-s2.0-85012864677 |
| РИНЦ: | 29486686 |
| OpenAlex: | W2589050450 |