Usnic Acid Derivatives Are Effective Inhibitors of Tyrosyl-DNA Phosphodiesterase 1 Full article
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Russian Journal of Bioorganic Chemistry
ISSN: 1068-1620 |
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| Output data | Year: 2017, Volume: 43, Number: 1, Pages: 84-90 Pages count : 7 DOI: 10.1134/S1068162017010125 | ||||||||
| Tags | tyrosyl-DNA phosphodiesterase 1; tyrosyl-DNA phosphodiesterase 1 inhibitors; usnic acid | ||||||||
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Abstract:
The synthesis of (+)-usnic acid derivatives is described. The derivatives contain one or two cyano groups, connected to the acetophenone fragment of dibenzofuran core by linkers of different length and character, or some other modifications. The influence of these compounds on the activity of recombinant human tyrosyl-DNA phosphodiesterase 1 and MCF-7 tumor cells' viability has been estimated. The data indicate a distinct dependence of functional characteristics of the compounds on their structure.
Cite:
Zakharenko A.L.
, Luzina O.A.
, Sokolov D.N.
, Zakharova O.D.
, Rakhmanova M.E.
, Chepanova A.A.
, Dyrkheeva N.S.
, Lavrik O.I.
, Salakhutdinov N.F.
Usnic Acid Derivatives Are Effective Inhibitors of Tyrosyl-DNA Phosphodiesterase 1
Russian Journal of Bioorganic Chemistry. 2017. V.43. N1. P.84-90. DOI: 10.1134/S1068162017010125 WOS Scopus РИНЦ OpenAlex
Usnic Acid Derivatives Are Effective Inhibitors of Tyrosyl-DNA Phosphodiesterase 1
Russian Journal of Bioorganic Chemistry. 2017. V.43. N1. P.84-90. DOI: 10.1134/S1068162017010125 WOS Scopus РИНЦ OpenAlex
Dates:
| Published print: | Jan 1, 2017 |
| Published online: | Feb 14, 2017 |
Identifiers:
| Web of science: | WOS:000396423800012 |
| Scopus: | 2-s2.0-85012864677 |
| Elibrary: | 29486686 |
| OpenAlex: | W2589050450 |