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Anti-influenza activity of monoterpene-derived substituted hexahydro-2H-chromenes Научная публикация

Журнал Bioorganic and Medicinal Chemistry
ISSN: 0968-0896 , E-ISSN: 1464-3391
Вых. Данные Год: 2016, Том: 24, Номер: 21, Страницы: 5158-5161 Страниц : 4 DOI: 10.1016/j.bmc.2016.08.037
Ключевые слова Influenza; Monoterpene; Antiviral; Chromene
Авторы Patrusheva Oksana S. 1 , Zarubaev Vladimir V. 2 , Shtro Anna A. 2 , Orshanskaya Yana R. 2 , Boldyrev Sergey A. 2 , Ilyina Irina V. 1,3 , Kurbakova Svetlana Yu. 1 , Korchagina Dina V. 1 , Volcho Konstantin P. 1,3 , Salakhutdinov Nariman F. 1,3
Организации
1 (Данные Web of science) Russian Acad Sci, Novosibirsk Organ Chem Inst, Siberian Branch, Novosibirsk 630090, Russia
2 (Данные Web of science) Influenza Res Inst, Dept Chemotherapy, 15-17 Prof Popova St, St Petersburg 197376, Russia
3 (Данные Web of science) Novosibirsk State Univ, Pirogova 2, Novosibirsk 630090, Russia

Реферат: The antiviral activity of 4-hydroxy-hexahydro-2H-chromenes and 4-fluorine-hexahydro-2H-chromenes with an aromatic substituent, synthesized from monoterpene (-)-verbenone, was studied for the first time. Five of 11 (45 per cent) of 4-hydroxy-hexahydro-2H-chromene-type compounds have been found to exhibit antiviral activity against influenza A virus of subtype H1N1pdm09. Although a portion of active compounds among 4-fluorine-containing series was fewer, just compound 5i that contains a fluorine substituent exhibited more potent anti-influenza activity along with low cytotoxicity. Thus two new promising types of antiviral compounds were identified. (C) 2016 Elsevier Ltd. All rights reserved.
Библиографическая ссылка: Patrusheva O.S. , Zarubaev V.V. , Shtro A.A. , Orshanskaya Y.R. , Boldyrev S.A. , Ilyina I.V. , Kurbakova S.Y. , Korchagina D.V. , Volcho K.P. , Salakhutdinov N.F.
Anti-influenza activity of monoterpene-derived substituted hexahydro-2H-chromenes
Bioorganic and Medicinal Chemistry. 2016. V.24. N21. P.5158-5161. DOI: 10.1016/j.bmc.2016.08.037 WOS Scopus РИНЦ OpenAlex
Даты:
Опубликована в печати: 1 нояб. 2016 г.
Идентификаторы БД:
Web of science: WOS:000386990200016
Scopus: 2-s2.0-84991480400
РИНЦ: 27572964
OpenAlex: W2516524698
Цитирование в БД:
БД Цитирований
Web of science 36
Scopus 34
РИНЦ 34
OpenAlex 36
Альметрики: