Anti-influenza activity of monoterpene-derived substituted hexahydro-2H-chromenes Full article
| Journal |
Bioorganic and Medicinal Chemistry
ISSN: 0968-0896 , E-ISSN: 1464-3391 |
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| Output data | Year: 2016, Volume: 24, Number: 21, Pages: 5158-5161 Pages count : 4 DOI: 10.1016/j.bmc.2016.08.037 | ||||||
| Tags | Influenza; Monoterpene; Antiviral; Chromene | ||||||
| Authors |
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Abstract:
The antiviral activity of 4-hydroxy-hexahydro-2H-chromenes and 4-fluorine-hexahydro-2H-chromenes with an aromatic substituent, synthesized from monoterpene (-)-verbenone, was studied for the first time. Five of 11 (45 per cent) of 4-hydroxy-hexahydro-2H-chromene-type compounds have been found to exhibit antiviral activity against influenza A virus of subtype H1N1pdm09. Although a portion of active compounds among 4-fluorine-containing series was fewer, just compound 5i that contains a fluorine substituent exhibited more potent anti-influenza activity along with low cytotoxicity. Thus two new promising types of antiviral compounds were identified. (C) 2016 Elsevier Ltd. All rights reserved.
Cite:
Patrusheva O.S.
, Zarubaev V.V.
, Shtro A.A.
, Orshanskaya Y.R.
, Boldyrev S.A.
, Ilyina I.V.
, Kurbakova S.Y.
, Korchagina D.V.
, Volcho K.P.
, Salakhutdinov N.F.
Anti-influenza activity of monoterpene-derived substituted hexahydro-2H-chromenes
Bioorganic and Medicinal Chemistry. 2016. V.24. N21. P.5158-5161. DOI: 10.1016/j.bmc.2016.08.037 WOS Scopus РИНЦ OpenAlex
Anti-influenza activity of monoterpene-derived substituted hexahydro-2H-chromenes
Bioorganic and Medicinal Chemistry. 2016. V.24. N21. P.5158-5161. DOI: 10.1016/j.bmc.2016.08.037 WOS Scopus РИНЦ OpenAlex
Dates:
| Published print: | Nov 1, 2016 |
Identifiers:
| Web of science: | WOS:000386990200016 |
| Scopus: | 2-s2.0-84991480400 |
| Elibrary: | 27572964 |
| OpenAlex: | W2516524698 |