Benzoquinone and naphthoquinone based redox-active labels for electrochemical detection of modified oligonucleotides on Au electrodes Full article
| Journal |
Tetrahedron Letters
ISSN: 0040-4039 |
||||||
|---|---|---|---|---|---|---|---|
| Output data | Year: 2016, Volume: 57, Number: 3, Pages: 392-395 Pages count : DOI: 10.1016/j.tetlet.2015.12.035 | ||||||
| Tags | Quinones; Redox-active labels; Electrochemical reduction; Cyclic voltammetry; Modified oligonucleotides | ||||||
| Authors |
|
||||||
| Affiliations |
|
Abstract:
The reaction of 1,4-benzoquinone and 1,4-naphthoquinone with beta-thiopropionic acid yielded 3-[(3,6-dioxocyclohexa-1,4-diene-1-yl)thio]propionic and 3-[(1,4-dioxo-1,4-dihydronaphthalene-2-yl)thio]propionic acids, respectively. These compounds were used to modify oligonucleotides to allow their electrochemical detection on the surface of Au electrodes using cyclic voltammetry. Electrochemical reduction of the corresponding amides, modeling the bonding of the redox-active labels with molecules that are not electrochemically active, was also studied. (C) 2015 Elsevier Ltd. All rights reserved.
Cite:
Shundrin L.A.
, Irtegova I.G.
, Vasilieva N.V.
, Khalfina I.A.
Benzoquinone and naphthoquinone based redox-active labels for electrochemical detection of modified oligonucleotides on Au electrodes
Tetrahedron Letters. 2016. V.57. N3. P.392-395. DOI: 10.1016/j.tetlet.2015.12.035 WOS Scopus РИНЦ OpenAlex
Benzoquinone and naphthoquinone based redox-active labels for electrochemical detection of modified oligonucleotides on Au electrodes
Tetrahedron Letters. 2016. V.57. N3. P.392-395. DOI: 10.1016/j.tetlet.2015.12.035 WOS Scopus РИНЦ OpenAlex
Dates:
| Published print: | Jan 1, 2016 |
Identifiers:
| Web of science: | WOS:000369556900039 |
| Scopus: | 2-s2.0-84953362834 |
| Elibrary: | 26929366 |
| OpenAlex: | W2217904519 |