Реферат: The review discusses the literature data on the structures of hypoglycemic compounds with different mechanisms of action. It is shown that many drugs acting on different biological targets have similar or identical structural moieties. Compounds containing a sulfonyl group, a 3-phenylpropanoic acid moiety or the indane ring, as well as derivatives of heterocyclic systems (quinoline, isoquinoline, benzoxazine, thiazolidine and so on) are presented. The approach to the design of multi target hypoglycemic drugs by combining different pharmacophoric groups in one molecule is considered. The prospects of the use of these agents for the treatment of type 2 diabetes are discussed. The bibliography includes 177 references.

Библиографическая ссылка: Rogachev A.D. , Kuranov S.O. , Salakhutdinov N.F.
Chemical approach to the design of effective antidiabetic agents
Russian Chemical Reviews. 2016. V.85. N12. P.1313-1337. DOI: 10.1070/RCR4624 WOS Scopus РИНЦ OpenAlex

Оригинальная: Рогачев А.Д. , Куранов С.О. , Салахутдинов Н.Ф.
Химический подход к разработке эффективных противодиабетических препаратов
Успехи химии/Uspekhi Khimii. 2016. Т.85. №12. С.1313-1337. DOI: 10.1070/RCR4624?locatt=labelRUSSIAN РИНЦ

Даты:

Опубликована online:	20 дек. 2016 г.
Опубликована в печати:	31 дек. 2016 г.

Идентификаторы БД:

Web of science:	WOS:000391302600003
Scopus:	2-s2.0-85007475087
РИНЦ:	32803839
OpenAlex:	W2332714892

Цитирование в БД:

БД	Цитирований
Web of science	5
Scopus	5
РИНЦ	5
OpenAlex	5

Альметрики: