Abstract: The review discusses the literature data on the structures of hypoglycemic compounds with different mechanisms of action. It is shown that many drugs acting on different biological targets have similar or identical structural moieties. Compounds containing a sulfonyl group, a 3-phenylpropanoic acid moiety or the indane ring, as well as derivatives of heterocyclic systems (quinoline, isoquinoline, benzoxazine, thiazolidine and so on) are presented. The approach to the design of multi target hypoglycemic drugs by combining different pharmacophoric groups in one molecule is considered. The prospects of the use of these agents for the treatment of type 2 diabetes are discussed. The bibliography includes 177 references.

Cite: Rogachev A.D. , Kuranov S.O. , Salakhutdinov N.F.
Chemical approach to the design of effective antidiabetic agents
Russian Chemical Reviews. 2016. V.85. N12. P.1313-1337. DOI: 10.1070/RCR4624 WOS Scopus РИНЦ OpenAlex

Original: Рогачев А.Д. , Куранов С.О. , Салахутдинов Н.Ф.
Химический подход к разработке эффективных противодиабетических препаратов
Успехи химии/Uspekhi Khimii. 2016. Т.85. №12. С.1313-1337. DOI: 10.1070/RCR4624?locatt=labelRUSSIAN РИНЦ

Dates:

Published online:	Dec 20, 2016
Published print:	Dec 31, 2016

Identifiers:

Web of science:	WOS:000391302600003
Scopus:	2-s2.0-85007475087
Elibrary:	32803839
OpenAlex:	W2332714892

Citing:

DB	Citing
Web of science	5
Scopus	5
Elibrary	5
OpenAlex	5

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