Synthesis and analgesic activity of new compounds combining azaadamantane and monoterpene moieties Научная публикация
| Журнал |
Medicinal Chemistry Research
ISSN: 1054-2523 , E-ISSN: 1554-8120 |
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| Вых. Данные | Год: 2015, Том: 24, Номер: 12, Страницы: 4146-4156 Страниц : 11 DOI: 10.1007/s00044-015-1464-z | ||||
| Ключевые слова | Monoterpene; Azaadamantane; Heterocyclic compounds; Analgesic activity; Acetic acid-induced writhing test; Hot plate test; CB1 receptor | ||||
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Реферат:
Synthesis of new compounds that combine the diazaadamantane and monoterpenoid moieties was carried out based on the reaction between dimethylbispidinone and monoterpene-derived aldehydes. Investigation of the analgesic activity of the obtained products revealed that compound 5a synthesized from (-)-myrtenal had a higher efficacy compared with the reference drug, diclofenac sodium, in the acetic acid-induced writhing and hot plate tests. Compound 5a exhibits a low acute toxicity and does not cause damage to the gastric mucosa, and its analgesic effect is, at least partially, mediated by the cannabinoid system involving CB1 receptors.
Библиографическая ссылка:
Ponomarev K.
, Pavlova A.
, Suslov E.
, Ardashov O.
, Korchagina D.
, Nefedov A.
, Tolstikova T.
, Volcho K.
, Salakhutdinov N.
Synthesis and analgesic activity of new compounds combining azaadamantane and monoterpene moieties
Medicinal Chemistry Research. 2015. V.24. N12. P.4146-4156. DOI: 10.1007/s00044-015-1464-z WOS Scopus РИНЦ OpenAlex
Synthesis and analgesic activity of new compounds combining azaadamantane and monoterpene moieties
Medicinal Chemistry Research. 2015. V.24. N12. P.4146-4156. DOI: 10.1007/s00044-015-1464-z WOS Scopus РИНЦ OpenAlex
Даты:
| Опубликована online: | 9 сент. 2015 г. |
| Опубликована в печати: | 1 дек. 2015 г. |
Идентификаторы БД:
| Web of science: | WOS:000363249100015 |
| Scopus: | 2-s2.0-84945462750 |
| РИНЦ: | 24967555 |
| OpenAlex: | W1885094257 |