Synthesis and analgesic activity of new compounds combining azaadamantane and monoterpene moieties Full article
| Journal |
Medicinal Chemistry Research
ISSN: 1054-2523 , E-ISSN: 1554-8120 |
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| Output data | Year: 2015, Volume: 24, Number: 12, Pages: 4146-4156 Pages count : 11 DOI: 10.1007/s00044-015-1464-z | ||||
| Tags | Monoterpene; Azaadamantane; Heterocyclic compounds; Analgesic activity; Acetic acid-induced writhing test; Hot plate test; CB1 receptor | ||||
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Abstract:
Synthesis of new compounds that combine the diazaadamantane and monoterpenoid moieties was carried out based on the reaction between dimethylbispidinone and monoterpene-derived aldehydes. Investigation of the analgesic activity of the obtained products revealed that compound 5a synthesized from (-)-myrtenal had a higher efficacy compared with the reference drug, diclofenac sodium, in the acetic acid-induced writhing and hot plate tests. Compound 5a exhibits a low acute toxicity and does not cause damage to the gastric mucosa, and its analgesic effect is, at least partially, mediated by the cannabinoid system involving CB1 receptors.
Cite:
Ponomarev K.
, Pavlova A.
, Suslov E.
, Ardashov O.
, Korchagina D.
, Nefedov A.
, Tolstikova T.
, Volcho K.
, Salakhutdinov N.
Synthesis and analgesic activity of new compounds combining azaadamantane and monoterpene moieties
Medicinal Chemistry Research. 2015. V.24. N12. P.4146-4156. DOI: 10.1007/s00044-015-1464-z WOS Scopus РИНЦ OpenAlex
Synthesis and analgesic activity of new compounds combining azaadamantane and monoterpene moieties
Medicinal Chemistry Research. 2015. V.24. N12. P.4146-4156. DOI: 10.1007/s00044-015-1464-z WOS Scopus РИНЦ OpenAlex
Dates:
| Published online: | Sep 9, 2015 |
| Published print: | Dec 1, 2015 |
Identifiers:
| Web of science: | WOS:000363249100015 |
| Scopus: | 2-s2.0-84945462750 |
| Elibrary: | 24967555 |
| OpenAlex: | W1885094257 |