Discovery of a new class of antiviral compounds: Camphor imine derivatives Научная публикация
| Журнал |
European Journal of Medicinal Chemistry
ISSN: 0223-5234 , E-ISSN: 1768-3254 |
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| Вых. Данные | Год: 2015, Том: 105, Страницы: 263-273 Страниц : DOI: 10.1016/j.ejmech.2015.10.010 | ||||||
| Ключевые слова | Influenza; Camphor derivatives; Antiviral; Cage compounds | ||||||
| Авторы |
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| Организации |
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Реферат:
A new class of compounds featuring a camphor moiety has been discovered that exhibits potent inhibitory activity against influenza A(H1N1)pdm09 and A(H5N1) viruses. The synthesized compounds were characterized by spectroscopic analysis; in addition the structures of compound 2 and 14 were elucidated by the X-ray diffraction technique. Structure activity relationship studies have been conducted to identify the 1,7,7-trimethylbicyclo[2.2.1]heptanes2-ylidene group as the key functional group responsible for the observed antiviral activity. The most potent antiviral compound is imine 2 with therapeutic index more than 500. (C) 2015 Elsevier Masson SAS. All rights reserved.
Библиографическая ссылка:
Sokolova A.S.
, Yarovaya O.I.
, Shernyukov A.V.
, Gatilov Y.V.
, Razumova Y.V.
, Zarubaev V.V.
, Tretiak T.S.
, Pokrovsky A.G.
, Kiselev O.I.
, Salakhutdinov N.F.
Discovery of a new class of antiviral compounds: Camphor imine derivatives
European Journal of Medicinal Chemistry. 2015. V.105. P.263-273. DOI: 10.1016/j.ejmech.2015.10.010 WOS Scopus РИНЦ OpenAlex
Discovery of a new class of antiviral compounds: Camphor imine derivatives
European Journal of Medicinal Chemistry. 2015. V.105. P.263-273. DOI: 10.1016/j.ejmech.2015.10.010 WOS Scopus РИНЦ OpenAlex
Даты:
| Опубликована в печати: | 1 нояб. 2015 г. |
Идентификаторы БД:
| Web of science: | WOS:000364891400018 |
| Scopus: | 2-s2.0-84944887540 |
| РИНЦ: | 24963073 |
| OpenAlex: | W2179174460 |