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Discovery of a new class of antiviral compounds: Camphor imine derivatives Full article

Journal European Journal of Medicinal Chemistry
ISSN: 0223-5234 , E-ISSN: 1768-3254
Output data Year: 2015, Volume: 105, Pages: 263-273 Pages count : DOI: 10.1016/j.ejmech.2015.10.010
Tags Influenza; Camphor derivatives; Antiviral; Cage compounds
Authors Sokolova Anastasiya S. 1,2 , Yarovaya Olga I. 1,2 , Shernyukov Andrey V. 1 , Gatilov Yuriy V. 1,2 , Razumova Yuliya V. 2 , Zarubaev Vladimir V. 3 , Tretiak Tatiana S. 3 , Pokrovsky Andrey G. 2 , Kiselev Oleg I. 3 , Salakhutdinov Nariman F. 1,2
Affiliations
1 (Данные Web of science) Russian Acad Sci, Siberian Branch, NN Vorozhtsov Novosibirsk Inst Organ Chem, Novosibirsk 630090, Russia
2 (Данные Web of science) Novosibirsk State Univ, Novosibirsk 630090, Russia
3 (Данные Web of science) Influenza Res Ctr, Dept Chemotherapy, St Petersburg 197376, Russia

Abstract: A new class of compounds featuring a camphor moiety has been discovered that exhibits potent inhibitory activity against influenza A(H1N1)pdm09 and A(H5N1) viruses. The synthesized compounds were characterized by spectroscopic analysis; in addition the structures of compound 2 and 14 were elucidated by the X-ray diffraction technique. Structure activity relationship studies have been conducted to identify the 1,7,7-trimethylbicyclo[2.2.1]heptanes2-ylidene group as the key functional group responsible for the observed antiviral activity. The most potent antiviral compound is imine 2 with therapeutic index more than 500. (C) 2015 Elsevier Masson SAS. All rights reserved.
Cite: Sokolova A.S. , Yarovaya O.I. , Shernyukov A.V. , Gatilov Y.V. , Razumova Y.V. , Zarubaev V.V. , Tretiak T.S. , Pokrovsky A.G. , Kiselev O.I. , Salakhutdinov N.F.
Discovery of a new class of antiviral compounds: Camphor imine derivatives
European Journal of Medicinal Chemistry. 2015. V.105. P.263-273. DOI: 10.1016/j.ejmech.2015.10.010 WOS Scopus РИНЦ OpenAlex
Dates:
Published print: Nov 1, 2015
Identifiers:
Web of science: WOS:000364891400018
Scopus: 2-s2.0-84944887540
Elibrary: 24963073
OpenAlex: W2179174460
Citing:
DB Citing
Web of science 82
Scopus 79
Elibrary 101
OpenAlex 93
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