Study of skin anti-ageing and anti-inflammatory effects of dihydroquercetin, natural triterpenoinds, and their synthetic derivatives

Study of skin anti-ageing and anti-inflammatory effects of dihydroquercetin, natural triterpenoinds, and their synthetic derivatives Научная публикация

Журнал

Russian Journal of Bioorganic Chemistry
ISSN: 1068-1620

Вых. Данные

Год: 2012, Том: 38, Номер: 3, Страницы: 328-334 Страниц : DOI: 10.1134/S1068162012030028

Ключевые слова

collagenase-1; triterpenoids; dihydroquercetin; photoageing; interleukin-8

Авторы

Lee Chan Woo ² , Park Nok Hyun ² , Kim Jin Woong ³ , Um Byung Hun ⁴ , Shpatov A. V. ¹ , Shults E. E. ¹ , Sorokina I. V. ¹ , Popov S. A. ¹

Организации

1	(Данные Web of science) Novosibirsk Organ Chem Inst, Novosibirsk 630090, Russia
2	(Данные Web of science) Amore Pacific Co, R&D Ctr, Yongin 446729, Gyeonggi Do, South Korea
3	(Данные Web of science) Hanyang Univ, Dept Appl Chem, Ansan 426791, Kyeonggi Do, South Korea
4	(Данные Web of science) Korea Inst Sci & Technol KIST, Gangneung Inst, Nat Prod Res Ctr, Kangnung 210340, Gangwon Do, South Korea

Accessible triterpenoids of ursane and lupane series, the flavonoid dihydroquercetin and their synthetic derivatives with polar substituents were tested in vitro for inhibition of collagenase 1 (MMP-1) in UVB irradiation assay. Ursolic acid and uvaol disuccinate were the most active inhibitors in the ursane series. In the lupane series, the best inhibition was manifested by carboxymethyl ester of betulonic acid and betulin succinates. Down- regulation of MMP-1 by dihydroquercetin and its synthetic derivatives surpassed the activity of a standard (retinoic acid).

Lee C.W. , Park N.H. , Kim J.W. , Um B.H. , Shpatov A.V. , Shults E.E. , Sorokina I.V. , Popov S.A.
Study of skin anti-ageing and anti-inflammatory effects of dihydroquercetin, natural triterpenoinds, and their synthetic derivatives
Russian Journal of Bioorganic Chemistry. 2012. V.38. N3. P.328-334. DOI: 10.1134/S1068162012030028 WOS Scopus РИНЦ

Опубликована в печати:	1 мая 2012 г.
Опубликована online:	23 мая 2012 г.

Web of science	WOS:000304408900013
Scopus	2-s2.0-84865457787
РИНЦ	20471406
OpenAlex	W2028426733