Phenolic compounds from Glycyrrhiza pallidiflora Maxim. and their cytotoxic activity

Phenolic compounds from Glycyrrhiza pallidiflora Maxim. and their cytotoxic activity Научная публикация

Журнал

Natural Product Research
ISSN: 1478-6419 , E-ISSN: 1478-6427

Вых. Данные

Год: 2017, Том: 31, Номер: 4, Страницы: 445-452 Страниц : DOI: 10.1080/14786419.2016.1188094

Ключевые слова

Glycyrrhiza pallidiflora; flavonoids; pterocarpans; isoflavonoids; cytotoxic activity

Авторы

Shults Elvira E. ^1,2 , Shakirov Makhmut M. ¹ , Pokrovsky Mikhail A. ² , Petrova Tatijana N. ¹ , Pokrovsky Andrey G. ² , Gorovoy Petr G. ³

Организации

1	(Данные Web of science) Russian Acad Sci, Novosibirsk Inst Organ Chem, Siberian Branch, Novosibirsk, Russia
2	(Данные Web of science) Novosibirsk State Univ, Med Dept, Novosibirsk, Russia
3	(Данные Web of science) Russian Acad Sci, Far Eastern Branch, GB Elyakov Pacific Inst Bioorgan Chem, Vladivostok, Russia

Twenty-one phenolic compounds (1-21) including dihydrocinnamic acid, isoflavonoids, flavonoids, coumestans, pterocarpans, chalcones, isoflavan and isoflaven, were isolated from the roots of Glycyrrhiza pallidiflora Maxim. Phloretinic acid (1), chrysin (6), 9-methoxycoumestan (8), isoglycyrol (9), 6"-O-acetylanonin (19) and 6"-O-acetylwistin (21) were isolated from G. pallidiflora for the first time. Isoflavonoid acetylglycosides 19, 21 might be artefacts that could be produced during the EtOAc fractionation process of whole extract. Compounds 2-4, 10, 11, 19 and 21 were evaluated for their cytotoxic activity with respect to model cancer cell lines (CEM-13, MT4, U-937) using the conventional MTT assays. Isoflavonoid calycosin (4) showed the best potency against human T-cell leukaemia cells MT-4 (CTD50, 2.9 mu M). Pterocarpans medicarpin (10) and homopterocarpin (11) exhibit anticancer activity in micromolar range with selectivity on the human monocyte cells U-937. The isoflavan (3R)-vestitol (16) was highly selective on the lymphoblastoid leukaemia cells CEM-13 and was more active than the drug doxorubicin [GRAPHICS] .

Shults E.E. , Shakirov M.M. , Pokrovsky M.A. , Petrova T.N. , Pokrovsky A.G. , Gorovoy P.G.
Phenolic compounds from Glycyrrhiza pallidiflora Maxim. and their cytotoxic activity
Natural Product Research. 2017. V.31. N4. P.445-452. DOI: 10.1080/14786419.2016.1188094 WOS Scopus РИНЦ

Опубликована online:	22 мая 2016 г.
Опубликована в печати:	16 февр. 2017 г.

Web of science	WOS:000392626400010
Scopus	2-s2.0-84969816543
РИНЦ	28464893
OpenAlex	W2399045633